UNIVERSITETSSJUKHUS SOM ERBJUDER FUNKTIONSMEDICINSK VÅRD/UTBILDNING
1. Cleveland Clinic, Ohio
https://my.clevelandclinic.org/departments/functional-medicine
2. Stanford Healthcare
3. Jefferson Health, Philadelphia
https://www.jeffersonhealth.org/conditions-and-treatments/functional-medicine
4. Vanderbilt Health, Nashville
https://my.vanderbilthealth.com/what-is-functional-medicine/ https://medschool.vanderbilt.edu/vanderbilt-medicine/innovations-improve-the-lives-of-patients-with-ibd/
https://www.vumc.org/pmr/person/barton-w-huddleston-md
5. George Washington University Hospital
https://gwcim.com/services/functional-medicine-dc/
https://www.youtube.com/watch?v=8P5viA0Roq8
6. Henry Ford Health, Michigan
https://www.henryford.com/services/center-for-integrative-medicine/functional-medicine
7. Stony Brook Southampton Hospital
https://southampton.stonybrookmedicine.edu/services/wellness-institute/functional-medicine
8. University of Minnesota Medical Center
DEN SENASTE FORSKNINGEN OM FUNKTIONSMEDICIN
Beyond the Biomedical Model: A Critical Review of the Approach to Chronic Pain and the Proposal of an Integrated Functional Model Cureus. 2025 Jun 10;17(6):e85717.
This review suggests the evolution towards a "bio-psycho-functional and social" model for a more complete understanding and management of chronic pain.
An Integrative Approach to HPA Axis Dysfunction: From Recognition to Recovery Am J Med. 2025 Oct;138(10):1451-1463.
By bridging conventional endocrinology and functional medicine, clinicians are better equipped to address commonly overlooked symptoms such as fatigue, insomnia, mood disturbances, and poor stress tolerance, ultimately enhancing patient outcomes.
Dietary associations with reduced epigenetic age: a secondary data analysis of the methylation diet and lifestyle study Aging (Albany NY). 2025 Apr 17;17(4):994-1010.
Functional Medicine Care was Associated with Lower Pharmacy Claims Costs Among Ashland School District Employee Health Plan Participants With Musculoskeletal Disorders Altern Ther Health Med. 2024 Oct;30(10):34-38.
Medical and pharmacy claims remained stable over the study period among employee health plan participants with musculoskeletal disorders, and functional medicine care was associated with significantly lower pharmacy claims costs.
Functional Medicine in Nursing Am J Nurs. 2024 Oct 1;124(10):32-40.
By adopting a functional medicine approach, nurses can promote a more personalized and collaborative health care environment that can improve patient outcomes and empower patients to take an active role in their own health journey.
Sustained Cognitive Improvement in Alzheimer's Disease Patients Following a Precision Medicine Protocol: Case Series Biomedicines. 2024 Aug 6;12(8):1776.
Here, we report sustained cognitive improvement, in some cases for over a decade, in patients treated with a precision medicine protocol-something that has not been reported in patients treated with anti-cholinesterase, glutamate receptor inhibitory, anti-amyloid, or other therapeutic methods.
A Virtual Functional Medicine-Based Interdisciplinary and Integrative Intervention for Gulf War Illness Mil Med. 2024 Aug 19;189(Suppl 3):99-105
These preliminary results demonstrate the possibility of creating positive health outcomes across multiple health indicators in medically complex combat-deployed Veterans.
Association of Intensive Lifestyle Intervention for Type 2 Diabetes With Labor Market Outcomes JAMA Intern Med. 2023 Oct 1;183(10):1071-1079.
The findings of this cohort study suggest that an intensive lifestyle intervention to prevent the progression and complications of type 2 diabetes was associated with higher levels of employment. These results validate functional medicine’s comprehensive, evidence-based approach to patient care, including intensive lifestyle changes.
Rationale for a Multi-Factorial Approach for the Reversal of Cognitive Decline in Alzheimer's Disease and MCI: A Review Int J Mol Sci. 2023 Jan 14;24(2):1659.
A multi-therapeutic program that simultaneously targets multiple factors underlying the AD network may be more effective than a mono-therapeutic approach.
Precision Medicine Approach to Alzheimer's Disease: Rationale and Implications J Alzheimers Dis. 2023;96(2):429-437.
Precision medicine approaches to AD, based on a novel model of AD pathophysiology, offer promise that has not been realized to date with monotherapeutic approaches.
Functional Medicine Approach to Patient Care Improves Sleep, Fatigue, and Quality of Life in Patients With Inflammatory Bowel Disease Crohns Colitis 360. 2022 Sep 8;4(3):otac032.
In this cohort, utilizing Functional Medicine as an adjunct to traditional care resulted in improvement in all PROs.
Precision Medicine Approach to Alzheimer's Disease: Successful Pilot Project J Alzheimers Dis. 2022;88(4):1411-1421.
All outcome measures revealed improvement: statistically significant improvement in MoCA scores, CNS Vital Signs Neurocognitive Index, and Alzheimer's Questionnaire Change score were documented. No serious adverse events were recorded. MRI volumetrics also improved.
Patient outcomes and costs associated with functional medicine-based care in a shared versus individual setting for patients with chronic conditions: a retrospective cohort study BMJ Open. 2021 Apr 13;11(4):e048294.
The functional medicine group exhibited greater improvements in patient-reported physical and mental health scores and lost more weight than those who had individual appointments.
The impact of functional medicine on patient-reported outcomes in inflammatory arthritis: A retrospective study PLoS One. 2020 Oct 8;15(10):e0240416.
Inflammatory arthritis patients treated with functional medicine at Cleveland Clinic's Center for Functional Medicine experienced improvements in all primary outcomes compared to those receiving standard care.
Association of the Functional Medicine Model of Care With Patient-Reported Health-Related Quality-of-Life Outcomes JAMA Netw Open. 2019 Oct 2;2(10):e1914017.
Patients treated at Cleveland Clinic's Center for Functional Medicine showed significant improvements in global physical health compared to those in a primary care setting, as measured by the NIH-validated PROMIS questionnaire.
N-of-1-studier:
A proposal to "Whole" our knowing: Clinical medicine in the Noosphere Explore (NY). 2025 Sep-Oct;21(5):103203.
This is the N-of-1 era where respect for differences in "knowing" requires a broad-based understanding of the entire spectrum of relationships that an individual experiences with their environment and lifestyle.
Quantification of personalized glycemic sensitivity to food and its potential for precision nutrition in a series of n-of-1 trials Am J Clin Nutr. 2025 Aug;122(2):502-512.
Our novel PGS provides a framework for quantity differences in glycemic sensitivity among healthy individuals and facilitates further research on tailored dietary advice that improves glucose homeostasis.
LIFEHOUSE's Functional Nutrition Examination (Physical Exam, Anthropometrics, and Selected Biomarkers) Informs Personalized Wellness Interventions J Pers Med. 2023 Mar 28;13(4):594.
Each individual has a unique and interacting set of genetic, lifestyle, and environmental factors that are reflected in their physical exam and laboratory biomarkers and significantly impact their experience of health. During LIFEHOUSE, we have documented physical exam, anthropometric, and biomarker findings that may increase the recognition of these wellness-challenging patterns in a population of 369 adults.
TIDIGARE FORSKNING OM FUNKTIONSMEDICIN I URVAL
Abbott RD, Sadowski A, Alt AG. Efficacy of the Autoimmune Protocol Diet as Part of a Multi-disciplinary, Supported Lifestyle Intervention for Hashimoto's Thyroiditis. Cureus. 2019 Apr 27;11(4):e4556.
Abbott RD, Sherwin K, Klopf H et al. Efficacy of a Multimodal Online Lifestyle Intervention for Depressive Symptoms and Quality of Life in Individuals With a History of Major Depressive Disorder. Cureus. 2020 Jul 8;12(7):e9061.
Arena R, Lavie CJ, Hivert MF, Williams MA, Briggs PD, Guazzi M. Who will deliver comprehensive healthy lifestyle interventions to combat non-communicable disease? Introducing the healthy lifestyle practitioner discipline. Expert Rev Cardiovasc Ther. 2016;14(1):15-22.
Beidelschies M, Alejandro-Rodriguez M, Ji X et al. Association of the Functional Medicine Model of Care With Patient-Reported Health-Related Quality-of-Life Outcomes. JAMA Network Open. 2019;2(10):e1914017.
Beidelschies M, Alejandro-Rodriguez M, Guo N et al. Patient outcomes and costs associated with functional medicine-based care in a shared versus individual setting for patients with chronic conditions: a retrospective cohort study. BMJ Open. 2021 Apr 13;11(4):e048294.
Bharmal N, Beidelschies M, Alejandro-Rodriguez M, Alejandro K, Guo N, Jones T, Bradley E. A nutrition and lifestyle-focused shared medical appointment in a resource-challenged community setting: a mixed-methods study. BMC Public Health. 2022 Mar 7;22(1):447.
Bredesen DE. Metabolic profiling distinguishes three subtypes of Alzheimer's disease. Aging (Albany NY). 2015 Aug;7(8):595-600.
Bredesen DE, Amos EC, Canick J et al. Reversal of cognitive decline in Alzheimer’s disease. Aging. June 2016;8(6):1250-1258.
D'Adamo CR, Grebinsky K, Roedersheimer G, Bowen-Jones K, Wagner E, Robinson S, Jones D. Functional Medicine Care was Associated with Lower Pharmacy Claims Costs Among Ashland School District Employee Health Plan Participants With Musculoskeletal Disorders. Altern Ther Health Med. 2024 Sep 24:AT11280.
Drisko J, Bischoff B, Hall M, McCallum R. Treating irritable bowel syndrome with a food elimination diet followed by food challenge and probiotics. J Am Coll Nutr. 2006 Dec;25(6):514-22.
Droz N, Hanaway P, Hyman M et al. The impact of functional medicine on patient-reported outcomes in inflammatory arthritis: A retrospective study. PLoS One. 2020 Oct 8;15(10):e0240416.
Fitzgerald KN, Hodges R, Hanes D, Stack E, Cheishvili D, Szyf M, Henkel J, Twedt MW, Giannopoulou D, Herdell J, Logan S, Bradley R. Potential reversal of epigenetic age using a diet and lifestyle intervention: a pilot randomized clinical trial. Aging (Albany NY). 2021 Apr 12;13.
Franic D, Snapp C, DeBusk R. Newly developed functional medicine program in diabetes: impact on clinical and patient reported outcomes – functional medicine and quality of life. BMC Complement Altern Med. 2012; 12(Suppl 1): P250.
Guarneri M, Mercado N, Suhar C. Integrative approaches for cardiovascular disease. Nutr Clin Pract. 2009;24(6):701-8
Haws K, Mak S, Greer S, Kussin CA, Sacra E, Carlson CJ, McManus P, Varon S, Chandler H, Osinubi O. A Virtual Functional Medicine-Based Interdisciplinary and Integrative Intervention for Gulf War Illness. Mil Med. 2024 Aug 19;189(Supplement_3):99-105.
Houston M. The role of cellular micronutrient analysis, nutraceuticals, vitamins, antioxidants and minerals in the prevention and treatment of hypertension and cardiovascular disease. Ther Adv Cardiovasc Dis. 2010;4(3):165-83.
James R, Moore AL, Carpenter D, Miller T, Ledbetter C. Feasibility of a Functional Medicine Approach to Slowing Clinical Cognitive Decline in Patients Over Age 55: A Multiple Case Study Report. OBM Integrative and Complementary Medicine. 2019 Sept;4(3).
Kimball SM, Mirhosseini N, Rankin BD, Fyie K, Guarneri M. Retrospective Analysis of Cardiovascular Disease Risk Parameters in Participants of a Preventive Health and Wellness Program. Integr Med (Encinitas). 2019 Jun;18(3):78-95.
Kushner RF, Sorensen KW. Lifestyle medicine: the future of chronic disease management. Curr Opin Endocrinol Diabetes Obes. 2013;20(5):389-95.
Lamb JJ, Stone M, D'Adamo CR, Volkov A, Metti D, Aronica L, Minich D, Leary M, Class M, Carullo M, Ryan JJ, Larson IA, Lundquist E, Contractor N, Eck B, Ordovas JM, Bland JS. Personalized Lifestyle Intervention and Functional Evaluation Health Outcomes SurvEy: Presentation of the LIFEHOUSE Study Using N-of-One Tent-Umbrella-Bucket Design. J Pers Med. 2022 Jan 15;12(1):115.
Orlando FA, Chang KL, Estores IM. Functional medicine: Focusing on imbalances in core metabolic processes. J Fam Pract. 2021 Dec;70(10):482-498.
Ring M. An Integrative Approach to HPA Axis Dysfunction: From Recognition to Recovery. Am J Med. 2025 Oct;138(10):1451-1463.
Schechter G, Azad GK, Rao R, McKeany A, Matulaitis M, Kalos DM, Kennedy BK. A Comprehensive, Multi-Modal Strategy to Mitigate Alzheimer's Disease Risk Factors Improves Aspects of Metabolism and Offsets Cognitive Decline in Individuals with Cognitive Impairment. J Alzheimers Dis Rep. 2020 Jun 29;4(1):223-230.
Svinarich JT. The functional medicine approach to atrial fibrillation: can a cure for atrial fibrillation be found in the gut? Curr Opin Cardiol. 2021 Jan;36(1):44-50.
